{"id":61756,"date":"2025-01-14T16:49:29","date_gmt":"2025-01-14T15:49:29","guid":{"rendered":"https:\/\/fhi.nl\/?post_type=news&#038;p=61756"},"modified":"2025-01-14T16:49:32","modified_gmt":"2025-01-14T15:49:32","slug":"speekselkliertransplantatie-een-doorbraak-na-twintig-jaar-onderzoek","status":"publish","type":"news","link":"https:\/\/fhi.nl\/en\/news\/speekselkliertransplantatie-een-doorbraak-na-twintig-jaar-onderzoek\/","title":{"rendered":"Salivary gland transplantation: a breakthrough after twenty years of research"},"content":{"rendered":"<header id=\"header\" class=\"header header--high header--branch\">\n\n\t\t\t\t\t\t\t\t\t\t<div class=\"header__background header__background--high\">\n\t\t\t\t\t<img decoding=\"async\" class=\"header__background-image\" src=\"https:\/\/fhi.nl\/app\/uploads\/2025\/01\/Afbeelding_kaakchirurg-1620x1080.jpg\" alt=\"\">\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\n\t<div class=\"container\">\n\t\t<div class=\"header__content\">\n\t\t\t<div class=\"header__first\">\n\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h6 class=\"header__subtitle\">By: Eline te Velde<\/h6>\n\t\t\t\t\n\t\t\t\t<h1 class=\"header__title\" >\n\t\t\t\t\tSalivary gland transplantation: a breakthrough after twenty years of research\t\t\t\t<\/h1>\n\n\t\t\t\t<div class=\"header__dots-line\">\n\t\t\t\t\t<svg width=\"431\" height=\"9\" viewbox=\"0 0 431 9\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M430.799 4.192a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.135 1.135 0 1 1-2.27 0 1.135 1.135 0 0 1 2.27 0Zm-27.27 0a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.39 1.39 0 1 1-2.78 0 1.39 1.39 0 0 1 2.78 0Zm-27.78 0a1.645 1.645 0 1 1-3.29 0 1.645 1.645 0 0 1 3.29 0Zm-28.29 0a1.9 1.9 0 1 1-3.799 0 1.9 1.9 0 0 1 3.799 0Zm-28.799 0a2.154 2.154 0 1 1-4.308 0 2.154 2.154 0 0 1 4.308 0Zm-29.308 0a2.41 2.41 0 1 1-4.819 0 2.41 2.41 0 0 1 4.819 0Zm-29.819 0a2.663 2.663 0 1 1-5.326.001 2.663 2.663 0 0 1 5.326-.001Zm-30.327 0a2.919 2.919 0 1 1-5.837 0 2.919 2.919 0 0 1 5.837 0Zm-30.837 0a3.173 3.173 0 1 1-6.345.001 3.173 3.173 0 0 1 6.345 0Zm-31.346 0a3.428 3.428 0 1 1-6.856 0 3.428 3.428 0 0 1 6.856 0Zm-31.856 0a3.683 3.683 0 1 1-7.365 0 3.683 3.683 0 0 1 7.365 0Zm-32.365 0a3.937 3.937 0 1 1-7.875 0 3.937 3.937 0 0 1 7.875 0Zm-32.874 0a4.192 4.192 0 1 1-8.384 0 4.192 4.192 0 0 1 8.384 0Z\" fill=\"#FFF960\"\/><\/svg>\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"header__second\">\n\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"header__branch-logos\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/fhi.nl\/app\/uploads\/2024\/02\/Laboratorium-technologie.svg\" class=\"header__branch-logo\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/header>\n\n\t<div class=\"header__meta\">\n\t<div class=\"container\">\n\t\t<div class=\"header__meta__category\">\n\n\t\t\t\t\t\t\t<div class=\"header__meta__detail\">\n\t\t\t\t\t<div>Branch<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_branches_kennishub=laboratorium-technologie\" class=\"header__meta__detail--branch\">\n\t\t\t\t\t\t\t\tLaboratory Technology\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<div class=\"text bg--offwhite\">\n\t<div class=\"container\">\n\t\t\t\t\t\t<div class=\"text__content text__content--1-col\">\n\t\t\t<p><strong>In December 2022, the University Medical Center Groningen (UMCG) performed a unique treatment. For the first time, a patient was treated with salivary gland organoid cells, grown from his own stem cells. This therapy is the result of more than twenty years of research led by Rob Coppes, professor of Radiotherapy at the UMCG. <\/strong><\/p>\n<p>\u201cIt\u2019s unique that you can develop an idea in one place and then eventually apply it in a clinical trial in the same place,\u201d says Coppes. The idea for this research came about in the early 2000s at a conference in Oxford. \u201cI saw a poster presentation about an experiment where cells were injected into the spinal cord of laboratory animals. The research showed a small improvement, and that planted a seed.\u201d<\/p>\n<p>The real breakthrough came a few years later through a chance meeting. \u201cOur department merged with the stem cell biology department. During conversations at the coffee machine I discovered that they had techniques that we could use. Together we submitted a grant proposal to KWF. In 2003 the research officially started.\u201d<\/p>\n<h4>\u00a0Organoids<\/h4>\n<p>The first steps were promising, but full of challenges. \u201cIn 2008, we showed that it was possible to isolate and culture stem cells from salivary glands,\u201d Coppes explains. \u201cIn that phase alone, we needed three mice to treat one mouse. Of course, that is not feasible in the clinic. An important breakthrough came from the research of Hans Clevers\u2019 group on organoids at the Hubrecht Institute. \u201cOrganoid technology took us much further. We lacked a few growth factors to grow high-quality organoids. It then took us six years to develop the method according to Good Manufacturing Practice (GMP) guidelines. After approval by the CCMO, the central medical ethics review committee, we were able to treat the first patient in December 2022.\u201d<\/p>\n<h4>Dry mouth<\/h4>\n<p>Xerostomia, a dry mouth due to reduced saliva production, is a common side effect of radiation for tumors in the head and neck area. Without functioning salivary glands, patients suffer from various complaints, such as loss of taste, difficulty speaking, swallowing and serious dental problems. \u201cIt has a huge impact on the quality of life,\u201d Coppes emphasizes. \u201cWithout saliva, you don\u2019t die, but life does become more unpleasant.\u201d<\/p>\n<p>The treatment is currently focused on a specific group of patients with a tumor in the oral cavity or near the tongue. \u201cIn these patients, the tumor is surgically removed, including one of the salivary glands. We receive a piece of the removed gland, grow it in the lab and make organoids from it. In the case of metastasis on the other side, the patient undergoes radiation. The same salivary gland on the other side is then severely damaged and no longer functional. The idea is that we replace the grown salivary gland after the radiotherapy.\u201d<\/p>\n<h4>Cooperation<\/h4>\n<p>Interdisciplinary collaboration was essential to make this research a success. \u201cWe collaborated with biomedical sciences, radiotherapy, stem cell biology, oral surgery, the ATMP department to do everything according to regulations and later with radiology. We were lucky that all these departments within the UMCG were willing to cooperate and had sufficient capacity.\u201d<\/p>\n<p>In addition to the enormous impact for the patient, Coppes gets a lot of satisfaction from the scientific process. \u201cThe best thing about this research is that you learn so much about how life works. Sometimes you discover by-catches that are unexpectedly valuable. For example, we now know exactly where the stem cells are in salivary glands. We have applied this knowledge to adjust radiation methods so that the stem cells are spared as much as possible. That helps patients before they even know what they are missing.\u201d<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\r\n\t<div class=\"articles bg--dark-blue items_selected\">\r\n\t\t<div class=\"container\">\r\n\t\t\t<div class=\"articles__header\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/\" class=\"button button--outline\">Read more<\/a>\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div class=\"post-grid post-grid--no-padding\">\r\n\t\t\t\t\n<a class=\"single-item single-item__articles\" href=\"https:\/\/fhi.nl\/en\/news\/infectiediagnostiek-onder-de-loep-met-metagenomics\/\" data-id=\"31643\">\n\t<div class=\"single-item__articles-icon\">\n\t\t<svg width=\"82\" height=\"98\" viewbox=\"0 0 82 98\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M26.5586 7.96501C26.5586 6.61879 26.8909 5.49682 27.3233 4.77796C27.7792 4.02009 28.1318 4 28.1466 4H55.0564C55.0712 4 55.4238 4.02009 55.8796 4.77796C56.312 5.49682 56.6444 6.61879 56.6444 7.96501C56.6444 9.31122 56.312 10.4332 55.8796 11.1521C55.4238 11.9099 55.0712 11.93 55.0564 11.93H54.2487C53.8841 11.5449 53.3681 11.3047 52.796 11.3047H28.981C28.5233 11.3047 28.1015 11.4584 27.7644 11.7171C27.6381 11.602 27.4874 11.4248 27.3233 11.1521C26.8909 10.4332 26.5586 9.31122 26.5586 7.96501ZM26.981 15.7683C25.6024 15.3755 24.5619 14.3215 23.8956 13.2138C23.0294 11.7738 22.5586 9.91326 22.5586 7.96501C22.5586 6.01675 23.0294 4.15622 23.8956 2.71619C24.7383 1.31517 26.1797 0 28.1466 0H55.0564C57.0232 0 58.4646 1.31517 59.3073 2.71619C60.1735 4.15622 60.6444 6.01675 60.6444 7.96501C60.6444 9.91326 60.1735 11.7738 59.3073 13.2138C58.4646 14.6148 57.0232 15.93 55.0564 15.93H54.796V40.3243L80.5327 84.0062L80.5391 84.0172L80.5503 84.0368C84.0711 90.2609 79.5954 97.9997 72.4362 97.9997H9.34052C2.18152 97.9997 -2.29415 90.2608 1.22665 84.0368C1.23243 84.0265 1.23831 84.0163 1.24428 84.0062L26.981 40.3243V15.7683ZM30.981 15.93V35.792H39.161C40.2655 35.792 41.161 36.6874 41.161 37.792C41.161 38.8966 40.2655 39.792 39.161 39.792H30.981V40.8697C30.981 41.2268 30.8854 41.5773 30.7041 41.8849L21.3184 57.8149H60.4585L51.0728 41.8849C50.8916 41.5773 50.796 41.2268 50.796 40.8697V15.93H30.981ZM62.8152 61.8148C62.8065 61.8149 62.7978 61.8149 62.7891 61.8149H19.4727C19.3082 61.8149 19.1484 61.7951 18.9954 61.7577L4.70016 86.0205C2.69212 89.5942 5.27194 93.9997 9.34052 93.9997H72.4362C76.5051 93.9997 79.0848 89.5941 77.0768 86.0205L62.8152 61.8148Z\" fill=\"#FFDA56\"\/>\n<\/svg>\n\t<\/div>\n\t<div class=\"single-item__articles-title\"><div class='heading-wrapper'><h3>Infection diagnosis under the microscope with metagenomics<\/h3><\/div><\/div>\n\t<div class=\"single-item__articles-terms\">\n\t\t\n\t\t\n\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Laboratory Technology<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Life Science<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Interview<\/span>\n\t\t\t\t\t<\/div>\n\t<div class=\"single-item__articles-author-date-wrapper\">\n\t\t\t\t\t<div class=\"single-item__articles-author\">\n\t\t\t\tFHI, Federation of Technology Industries\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"single-item__articles-date\">\n\t\t\t\tApril 2, 2024\t\t\t<\/div>\n\t\t\t<\/div>\n<\/a>\n\n<a class=\"single-item single-item__articles\" href=\"https:\/\/fhi.nl\/en\/news\/bioluminescentie-maakt-snelle-dna-detectie-in-infectiediagnostiek-mogelijk\/\" data-id=\"31716\">\n\t<div class=\"single-item__articles-icon\">\n\t\t<svg width=\"35\" height=\"35\" viewbox=\"0 0 35 35\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n<mask id=\"mask0_1182_5532\" style=\"mask-type:luminance\" maskunits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"35\" height=\"35\">\n<path d=\"M0 0H35V35H0V0Z\" fill=\"white\"\/>\n<\/mask>\n<g mask=\"url(#mask0_1182_5532)\">\n<path d=\"M5.12695 9.22852H1.02539V31.9238H10.4299C12.2868 31.9238 14.0678 32.6615 15.3809 33.9746H19.6191C20.9322 32.6615 22.7132 31.9238 24.5701 31.9238H33.9746V11.2793H29.873\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M17.5 9.22852H18.1426C20.0088 7.89544 22.2237 7.17773 24.5615 7.17773H29.873V27.8223H24.5615C22.2237 27.8223 20.0088 28.54 18.1426 29.873H16.8574C14.9912 28.54 12.7763 27.8223 10.4385 27.8223H5.12695V5.12695H9.22852\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M9.22852 1.02539V21.6699C13.759 21.6699 17.5 25.3425 17.5 29.873V9.22852C17.5 4.698 13.759 1.02539 9.22852 1.02539Z\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<\/g>\n<\/svg>\n\t<\/div>\n\t<div class=\"single-item__articles-title\"><div class='heading-wrapper'><h3>Bioluminescence enables rapid DNA detection in infection diagnostics<\/h3><\/div><\/div>\n\t<div class=\"single-item__articles-terms\">\n\t\t\n\t\t\n\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Laboratory Technology<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Life Science<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Analysis<\/span>\n\t\t\t\t\t<\/div>\n\t<div class=\"single-item__articles-author-date-wrapper\">\n\t\t\t\t\t<div class=\"single-item__articles-author\">\n\t\t\t\tFHI, Federation of Technology Industries\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"single-item__articles-date\">\n\t\t\t\tMarch 20, 2024\t\t\t<\/div>\n\t\t\t<\/div>\n<\/a>\n\n<a class=\"single-item single-item__articles\" href=\"https:\/\/fhi.nl\/en\/news\/geneesmiddelen-op-maat-met-farmacogenetica\/\" data-id=\"31682\">\n\t<div class=\"single-item__articles-icon\">\n\t\t<svg width=\"35\" height=\"35\" viewbox=\"0 0 35 35\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n<mask id=\"mask0_1182_5532\" style=\"mask-type:luminance\" maskunits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"35\" height=\"35\">\n<path d=\"M0 0H35V35H0V0Z\" fill=\"white\"\/>\n<\/mask>\n<g mask=\"url(#mask0_1182_5532)\">\n<path d=\"M5.12695 9.22852H1.02539V31.9238H10.4299C12.2868 31.9238 14.0678 32.6615 15.3809 33.9746H19.6191C20.9322 32.6615 22.7132 31.9238 24.5701 31.9238H33.9746V11.2793H29.873\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M17.5 9.22852H18.1426C20.0088 7.89544 22.2237 7.17773 24.5615 7.17773H29.873V27.8223H24.5615C22.2237 27.8223 20.0088 28.54 18.1426 29.873H16.8574C14.9912 28.54 12.7763 27.8223 10.4385 27.8223H5.12695V5.12695H9.22852\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M9.22852 1.02539V21.6699C13.759 21.6699 17.5 25.3425 17.5 29.873V9.22852C17.5 4.698 13.759 1.02539 9.22852 1.02539Z\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<\/g>\n<\/svg>\n\t<\/div>\n\t<div class=\"single-item__articles-title\"><div class='heading-wrapper'><h3>Customized medicines with pharmacogenetics<\/h3><\/div><\/div>\n\t<div class=\"single-item__articles-terms\">\n\t\t\n\t\t\n\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Laboratory Technology<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Life Science<\/span>\n\t\t\t\t\t<\/div>\n\t<div class=\"single-item__articles-author-date-wrapper\">\n\t\t\t\t\t<div class=\"single-item__articles-author\">\n\t\t\t\tFHI, Federation of Technology Industries\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"single-item__articles-date\">\n\t\t\t\tMarch 27, 2024\t\t\t<\/div>\n\t\t\t<\/div>\n<\/a>\n\t\t\t<\/div>\r\n\t\t<\/div>\r\n\t<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","branches":[14],"events":[369],"secretariat":[],"categories":[],"themes_tax":[517],"content_types":[],"class_list":["post-61756","news","type-news","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Speekselkliertransplantatie: een doorbraak na twintig jaar onderzoek - FHI, federatie van technologiebranches<\/title>\n<meta name=\"description\" content=\"In december 2022 voerde het Universitair Medisch Centrum Groningen (UMCG) een unieke behandeling uit. Voor het eerst werd een pati\u00ebnt behandeld met cellen van speekselklier-organo\u00efden, gekweekt uit zijn eigen stamcellen. Deze therapie is het resultaat van ruim twintig jaar onderzoek onder leiding van Rob Coppes, hoogleraar Radiotherapie bij het UMCG.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhi.nl\/en\/nieuws\/speekselkliertransplantatie-een-doorbraak-na-twintig-jaar-onderzoek\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Speekselkliertransplantatie: een doorbraak na twintig jaar onderzoek - FHI, federatie van technologiebranches\" \/>\n<meta property=\"og:description\" content=\"In december 2022 voerde het Universitair Medisch Centrum Groningen (UMCG) een unieke behandeling uit. Voor het eerst werd een pati\u00ebnt behandeld met cellen van speekselklier-organo\u00efden, gekweekt uit zijn eigen stamcellen. Deze therapie is het resultaat van ruim twintig jaar onderzoek onder leiding van Rob Coppes, hoogleraar Radiotherapie bij het UMCG.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhi.nl\/en\/nieuws\/speekselkliertransplantatie-een-doorbraak-na-twintig-jaar-onderzoek\/\" \/>\n<meta property=\"og:site_name\" content=\"FHI, federatie van technologiebranches\" \/>\n<meta property=\"article:modified_time\" content=\"2025-01-14T15:49:32+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhi.nl\/nieuws\/speekselkliertransplantatie-een-doorbraak-na-twintig-jaar-onderzoek\/\",\"url\":\"https:\/\/fhi.nl\/nieuws\/speekselkliertransplantatie-een-doorbraak-na-twintig-jaar-onderzoek\/\",\"name\":\"Speekselkliertransplantatie: een doorbraak na twintig jaar onderzoek - FHI, federatie van technologiebranches\",\"isPartOf\":{\"@id\":\"https:\/\/fhi.nl\/#website\"},\"datePublished\":\"2025-01-14T15:49:29+00:00\",\"dateModified\":\"2025-01-14T15:49:32+00:00\",\"description\":\"In december 2022 voerde het Universitair Medisch Centrum Groningen (UMCG) een unieke behandeling uit. 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