{"id":84457,"date":"2026-06-23T12:15:00","date_gmt":"2026-06-23T10:15:00","guid":{"rendered":"https:\/\/fhi.nl\/?post_type=news&#038;p=84457"},"modified":"2026-06-23T12:23:59","modified_gmt":"2026-06-23T10:23:59","slug":"s-trap-sample-prep-betrouwbare-eiwitdigestie-voor-proteomics-workflows","status":"publish","type":"news","link":"https:\/\/fhi.nl\/en\/news\/s-trap-sample-prep-betrouwbare-eiwitdigestie-voor-proteomics-workflows\/","title":{"rendered":"S-Trap\u2122 sample prep: reliable protein digestion for proteomics workflows!"},"content":{"rendered":"<header id=\"header\" class=\"header header--low header--branch\">\n\n\t\n\t\t\t<div class=\"header__background header__background--graphic\"><\/div>\n\t\n\t<div class=\"container\">\n\t\t<div class=\"header__content\">\n\t\t\t<div class=\"header__first\">\n\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<h1 class=\"header__title\" >\n\t\t\t\t\tS-Trap\u2122 sample prep: reliable protein digestion for proteomics workflows!\t\t\t\t<\/h1>\n\n\t\t\t\t<div class=\"header__dots-line\">\n\t\t\t\t\t<svg width=\"431\" height=\"9\" viewbox=\"0 0 431 9\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M430.799 4.192a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.135 1.135 0 1 1-2.27 0 1.135 1.135 0 0 1 2.27 0Zm-27.27 0a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.39 1.39 0 1 1-2.78 0 1.39 1.39 0 0 1 2.78 0Zm-27.78 0a1.645 1.645 0 1 1-3.29 0 1.645 1.645 0 0 1 3.29 0Zm-28.29 0a1.9 1.9 0 1 1-3.799 0 1.9 1.9 0 0 1 3.799 0Zm-28.799 0a2.154 2.154 0 1 1-4.308 0 2.154 2.154 0 0 1 4.308 0Zm-29.308 0a2.41 2.41 0 1 1-4.819 0 2.41 2.41 0 0 1 4.819 0Zm-29.819 0a2.663 2.663 0 1 1-5.326.001 2.663 2.663 0 0 1 5.326-.001Zm-30.327 0a2.919 2.919 0 1 1-5.837 0 2.919 2.919 0 0 1 5.837 0Zm-30.837 0a3.173 3.173 0 1 1-6.345.001 3.173 3.173 0 0 1 6.345 0Zm-31.346 0a3.428 3.428 0 1 1-6.856 0 3.428 3.428 0 0 1 6.856 0Zm-31.856 0a3.683 3.683 0 1 1-7.365 0 3.683 3.683 0 0 1 7.365 0Zm-32.365 0a3.937 3.937 0 1 1-7.875 0 3.937 3.937 0 0 1 7.875 0Zm-32.874 0a4.192 4.192 0 1 1-8.384 0 4.192 4.192 0 0 1 8.384 0Z\" fill=\"#FFF960\"\/><\/svg>\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"header__second\">\n\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"header__branch-logos\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/fhi.nl\/app\/uploads\/2024\/02\/Laboratorium-technologie.svg\" class=\"header__branch-logo\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/header>\n\n\t<div class=\"header__meta\">\n\t<div class=\"container\">\n\t\t<div class=\"header__meta__category\">\n\n\t\t\t\t\t\t\t<div class=\"header__meta__detail\">\n\t\t\t\t\t<div>Branch<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_branches_kennishub=laboratorium-technologie\" class=\"header__meta__detail--branch\">\n\t\t\t\t\t\t\t\tLaboratory Technology\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"header__meta__detail\">\n\t\t\t\t\t<div>Subject<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_onderwerp_kennishub=labanalyse\" class=\"header__meta__detail--categorie\">\n\t\t\t\t\t\t\t\tLabAnalysis\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_onderwerp_kennishub=laboratorium-technologie\" class=\"header__meta__detail--categorie\">\n\t\t\t\t\t\t\t\tLaboratory Technology\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_onderwerp_kennishub=life-science-biotechnologie\" class=\"header__meta__detail--categorie\">\n\t\t\t\t\t\t\t\tLife Science\/Biotechnology\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"text bg--white\">\n\t<div class=\"container\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"text__content text__content--1-col\">\n\t\t\t<h1>S-Trap\u2122 sample prep for reliable proteomics workflows<\/h1>\r\n<p class=\"isSelectedEnd\">A good LC-MS\/MS analysis does not start only at the mass spectrometer. Sample preparation is at least as important.<\/p>\r\n<p class=\"isSelectedEnd\">In proteomics, proteins must be properly dissolved, purified, and digested. If this step does not proceed correctly, it can affect the quality of the data. Substances such as salts, detergents, or buffers can also interfere with the analysis.<\/p>\r\n<p class=\"isSelectedEnd\"><a href=\"https:\/\/www.mswil.com\/sample-prep\/s-trap\/\">S-Trap\u2122 sample prep<\/a> helps to make this step simpler and more controllable.<\/p>\r\n<h2>Why sample prep is important<\/h2>\r\n<p class=\"isSelectedEnd\">Many laboratories work with complex samples. Think of cells, tissues, plasma, or other biological samples. These samples often contain substances that the <a href=\"https:\/\/www.mswil.com\/\">LC-MS\/MS analysis<\/a> can influence.<\/p>\r\n<p class=\"isSelectedEnd\">Therefore, a good sample preparation step is important. This step helps to prepare proteins for further analysis. It also helps to remove interfering substances.<\/p>\r\n<p class=\"isSelectedEnd\">For labs that want reliable proteomics data, this is an important part of the workflow.<\/p>\r\n<h2>What does S-Trap\u2122 do?<\/h2>\r\n<p class=\"isSelectedEnd\"><a href=\"https:\/\/www.mswil.com\/sample-prep\/s-trap\/\">S-Trap\u2122<\/a> has been developed for protein digestion in proteomics workflows. The method makes it possible to first thoroughly dissolve proteins with SDS. SDS is a strong substance that helps to effectively dissolve proteins, including membrane proteins.<\/p>\r\n<p class=\"isSelectedEnd\">Subsequently, the proteins are retained in the S-Trap\u2122. Interfering substances, such as detergents, salts, PEG, glycerol, and buffers, can then be removed.<\/p>\r\n<p class=\"isSelectedEnd\">After these washing steps, a protease is added. This enzyme digests the proteins into peptides. These peptides can then be used for LC-MS\/MS analysis.<\/p>\r\n<h2>Various sizes<\/h2>\r\n<p class=\"isSelectedEnd\">Not every lab processes the same amount of sample. Therefore, <a href=\"https:\/\/www.mswil.com\/sample-prep\/s-trap\/\">S-Trap\u2122<\/a> available in multiple formats.<\/p>\r\n<p class=\"isSelectedEnd\">The S-Trap\u2122 Micro Columns are suitable for smaller quantities of protein. The Mini Columns are intended for medium-sized samples. For larger quantities, there are Midi Columns.<\/p>\r\n<p class=\"isSelectedEnd\">For labs that process many samples simultaneously, there are also 96-well plates. These are suitable for high-throughput workflows and can help make the preparation of larger numbers of samples easier.<\/p>\r\n<p class=\"isSelectedEnd\">The S-Trap\u2122 product line includes:<\/p>\r\n<ul data-spread=\"false\">\r\n<li>Micro Columns<\/li>\r\n<li>Mini Columns<\/li>\r\n<li>Midi Columns<\/li>\r\n<li>96-well Micro Plates<\/li>\r\n<li>96-well Mini Plates<\/li>\r\n<li>complete kits with necessary solutions<\/li>\r\n<\/ul>\r\n<h2>A practical workflow choice<\/h2>\r\n<p class=\"isSelectedEnd\">The choice of sample prep depends on the type of sample, the amount of protein, and the number of samples. The existing LC-MS\/MS setup also plays a role.<\/p>\r\n<p class=\"isSelectedEnd\">Therefore, sample prep is not just a product choice. It is primarily a workflow choice.<\/p>\r\n<p class=\"isSelectedEnd\"><a href=\"https:\/\/www.mswil.com\/\">MS Will<\/a> supports European laboratories in finding a suitable route. This may involve protein digestion, protein enrichment, peptide enrichment, or other steps within the LC-MS\/MS workflow.<\/p>\r\n<p class=\"isSelectedEnd\">Within the broader <a href=\"https:\/\/www.mswil.com\/sample-prep\/\">sample prep portfolio<\/a> MS Wil offers various solutions for proteomics labs.<\/p>\r\n<h2>Practical support by MS Wil<\/h2>\r\n<p class=\"isSelectedEnd\"><a href=\"https:\/\/www.mswil.com\/\">MS Will<\/a> supplies specialist products for sample preparation, LC-MS\/MS, and mass spectrometry. The emphasis is on practical support, freedom of choice, and products that fit within existing workflows.<\/p>\r\n<p class=\"isSelectedEnd\">For labs that want to improve their proteomics sample prep, can <a href=\"https:\/\/www.mswil.com\/sample-prep\/s-trap\/\">S-Trap\u2122<\/a> be a practical solution. It helps to efficiently prepare proteins for LC-MS\/MS analysis, without the need for a completely new workflow.<\/p>\r\n<p>More information about S-Trap\u2122 is available via the MS Wil product page:<br \/><a href=\"https:\/\/www.mswil.com\/sample-prep\/s-trap\/\">https:\/\/www.mswil.com\/sample-prep\/s-trap\/<\/a><\/p>\t\t<\/div>\n\t<\/div>\n<\/div>\r\n\t<div class=\"articles bg--offwhite automatic\">\r\n\t\t<div class=\"container\">\r\n\t\t\t<div class=\"articles__header\">\r\n\t\t\t\t\t\t\t\t\t<div class='heading-wrapper'><svg width=\"13\" height=\"13\" viewbox=\"0 0 13 13\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"6.394\" cy=\"6.5\" r=\"6.394\" fill=\"#000\"\/><\/svg><h2>Related articles<\/h2><\/div>\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/en\/profiel\/ms-wil-b-v\/\" class=\"button button--outline\">view profile<\/a>\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div class=\"post-grid post-grid--no-padding\">\r\n\t\t\t\t\n<a class=\"single-item single-item__articles\" href=\"https:\/\/fhi.nl\/en\/news\/technology-thursday-the-final-steps\/\" data-id=\"40020\">\n\t<div class=\"single-item__articles-icon\">\n\t\t<svg width=\"103\" height=\"103\" viewbox=\"0 0 103 103\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M49.5 98.9587V82.3076C33.3844 81.2758 20.6328 67.878 20.6328 51.5019C20.6328 35.1258 33.3844 21.728 49.5 20.6962V4.04134C24.1941 5.08952 4 25.9365 4 51.5C4 77.0635 24.1941 97.9105 49.5 98.9587ZM53.5 78.2983V61.8096H76.3238C72.5238 70.9498 63.8222 77.5397 53.5 78.2983ZM49.5 78.298V61.8096H26.681C30.4804 70.9484 39.1799 77.5377 49.5 78.298ZM47.0728 57.8096H25.3773C24.8906 55.7865 24.6328 53.6743 24.6328 51.5019C24.6328 37.3358 35.5955 25.7301 49.5 24.7058V37.013H34.0466C33.2709 37.013 32.5653 37.4615 32.2359 38.1637C31.9065 38.8659 32.0128 39.6952 32.5086 40.2916L47.0728 57.8096ZM55.9249 57.8096H77.6274C78.1141 55.7865 78.3719 53.6743 78.3719 51.5019C78.3719 37.3342 67.4068 25.7275 53.5 24.7055V37.013H68.9511C69.7268 37.013 70.4324 37.4615 70.7618 38.1637C71.0912 38.8659 70.9849 39.6952 70.4891 40.2916L55.9249 57.8096ZM53.5 82.3079V98.9587C78.8059 97.9105 99 77.0635 99 51.5C99 25.9365 78.8059 5.08952 53.5 4.04134V20.6959C69.6178 21.7254 82.3719 35.1242 82.3719 51.5019C82.3719 67.8796 69.6178 81.2784 53.5 82.3079ZM0 51.5C0 23.7271 21.9843 1.08883 49.5 0.0381213V0H51.5H53.5V0.0381213C81.0157 1.08883 103 23.7271 103 51.5C103 79.9427 79.9427 103 51.5 103C23.0573 103 0 79.9427 0 51.5ZM38.3102 41.013H64.6875L51.4989 56.8765L38.3102 41.013Z\" fill=\"#2DD881\"\/>\n<\/svg>\n\t<\/div>\n\t<div class=\"single-item__articles-title\"><div class='heading-wrapper'><h3>Technology Thursday: The Final Steps<\/h3><\/div><\/div>\n\t<div class=\"single-item__articles-terms\">\n\t\t\n\t\t\n\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Industrial Electronics<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Design Automation &amp; Embedded Systems Event<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Members content<\/span>\n\t\t\t\t\t<\/div>\n\t<div class=\"single-item__articles-author-date-wrapper\">\n\t\t\t\t\t<div class=\"single-item__articles-author\">\n\t\t\t\tEurocircuits NV\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"single-item__articles-date\">\n\t\t\t\tJanuary 28, 2021\t\t\t<\/div>\n\t\t\t<\/div>\n<\/a>\n\n<a class=\"single-item single-item__articles\" href=\"https:\/\/fhi.nl\/en\/news\/lewa-breidt-ecosmart-lijn-uit-lcc-en-lcd-doseerpompen-met-hogere-capaciteiten\/\" data-id=\"35483\">\n\t<div class=\"single-item__articles-icon\">\n\t\t<svg width=\"35\" height=\"35\" viewbox=\"0 0 35 35\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n<mask id=\"mask0_1182_5532\" style=\"mask-type:luminance\" maskunits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"35\" height=\"35\">\n<path d=\"M0 0H35V35H0V0Z\" fill=\"white\"\/>\n<\/mask>\n<g mask=\"url(#mask0_1182_5532)\">\n<path d=\"M5.12695 9.22852H1.02539V31.9238H10.4299C12.2868 31.9238 14.0678 32.6615 15.3809 33.9746H19.6191C20.9322 32.6615 22.7132 31.9238 24.5701 31.9238H33.9746V11.2793H29.873\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M17.5 9.22852H18.1426C20.0088 7.89544 22.2237 7.17773 24.5615 7.17773H29.873V27.8223H24.5615C22.2237 27.8223 20.0088 28.54 18.1426 29.873H16.8574C14.9912 28.54 12.7763 27.8223 10.4385 27.8223H5.12695V5.12695H9.22852\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M9.22852 1.02539V21.6699C13.759 21.6699 17.5 25.3425 17.5 29.873V9.22852C17.5 4.698 13.759 1.02539 9.22852 1.02539Z\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<\/g>\n<\/svg>\n\t<\/div>\n\t<div class=\"single-item__articles-title\"><div class='heading-wrapper'><h3>LEWA expands ecosmart\u00ae line: LCC and LCD metering pumps with higher capacities<\/h3><\/div><\/div>\n\t<div class=\"single-item__articles-terms\">\n\t\t\n\t\t\n\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">World of Industry, Technology &amp; Science<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Members content<\/span>\n\t\t\t\t\t<\/div>\n\t<div class=\"single-item__articles-author-date-wrapper\">\n\t\t\t\t\t<div class=\"single-item__articles-author\">\n\t\t\t\tGeveke Pumps\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"single-item__articles-date\">\n\t\t\t\tJuly 5, 2022\t\t\t<\/div>\n\t\t\t<\/div>\n<\/a>\n\t\t\t<\/div>\r\n\t\t<\/div>\r\n\t<\/div>","protected":false},"excerpt":{"rendered":"<p>This article describes how S-Trap\u2122 sample prep can contribute to reproducible protein digestion within LC-MS\/MS proteomics workflows. The emphasis is on the importance of sample preparation as a basis for reliable data, the ability to use SDS, the removal of interfering components, and the availability of various formats, including spin columns, 96-well plates, and complete kits. MS Wil positions S-Trap\u2122 as a practical workflow route for European proteomics labs looking to improve their existing LC-MS\/MS workflow.<\/p>","protected":false},"featured_media":0,"template":"","branches":[14],"events":[],"secretariat":[],"categories":[427,59,32],"themes_tax":[524,513],"content_types":[514],"class_list":["post-84457","news","type-news","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>S-Trap sample prep voor proteomics workflows | MS Wil<\/title>\n<meta name=\"description\" content=\"Ontdek hoe S-Trap\u2122 sample prep kan helpen bij reproduceerbare eiwitdigestie voor LC-MS\/MS proteomics workflows, van spin columns tot 96-well plates.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.mswil.com\/sample-prep\/s-trap\/\" 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