{"id":90922,"date":"2026-11-07T23:35:09","date_gmt":"2026-11-07T22:35:09","guid":{"rendered":"https:\/\/fhi.nl\/nieuws\/usp-physical-parameters-wat-moet-u-controleren\/"},"modified":"2026-11-07T23:35:09","modified_gmt":"2026-11-07T22:35:09","slug":"usp-physical-parameters-wat-moet-u-controleren","status":"publish","type":"news","link":"https:\/\/fhi.nl\/en\/news\/usp-physical-parameters-wat-moet-u-controleren\/","title":{"rendered":"USP Physical Parameters: what should you check?"},"content":{"rendered":"\n<header id=\"header\" class=\"header header--low \">\n\n\t\n\t\t\t<div class=\"header__background header__background--graphic\"><\/div>\n\t\n\t<div class=\"container\">\n\t\t<div class=\"header__content\">\n\t\t\t<div class=\"header__first header__first--alone\">\n\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<h1 class=\"header__title\" >\n\t\t\t\t\tUSP Physical Parameters: wat moet u controleren?\t\t\t\t<\/h1>\n\n\t\t\t\t<div class=\"header__dots-line\">\n\t\t\t\t\t<svg width=\"431\" height=\"9\" viewBox=\"0 0 431 9\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M430.799 4.192a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.135 1.135 0 1 1-2.27 0 1.135 1.135 0 0 1 2.27 0Zm-27.27 0a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.39 1.39 0 1 1-2.78 0 1.39 1.39 0 0 1 2.78 0Zm-27.78 0a1.645 1.645 0 1 1-3.29 0 1.645 1.645 0 0 1 3.29 0Zm-28.29 0a1.9 1.9 0 1 1-3.799 0 1.9 1.9 0 0 1 3.799 0Zm-28.799 0a2.154 2.154 0 1 1-4.308 0 2.154 2.154 0 0 1 4.308 0Zm-29.308 0a2.41 2.41 0 1 1-4.819 0 2.41 2.41 0 0 1 4.819 0Zm-29.819 0a2.663 2.663 0 1 1-5.326.001 2.663 2.663 0 0 1 5.326-.001Zm-30.327 0a2.919 2.919 0 1 1-5.837 0 2.919 2.919 0 0 1 5.837 0Zm-30.837 0a3.173 3.173 0 1 1-6.345.001 3.173 3.173 0 0 1 6.345 0Zm-31.346 0a3.428 3.428 0 1 1-6.856 0 3.428 3.428 0 0 1 6.856 0Zm-31.856 0a3.683 3.683 0 1 1-7.365 0 3.683 3.683 0 0 1 7.365 0Zm-32.365 0a3.937 3.937 0 1 1-7.875 0 3.937 3.937 0 0 1 7.875 0Zm-32.874 0a4.192 4.192 0 1 1-8.384 0 4.192 4.192 0 0 1 8.384 0Z\" fill=\"#FFF960\"\/><\/svg>\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/header>\n\n\n\n<div class=\"text bg--white\">\n\t<div class=\"container\">\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"text__content text__content--1-col\">\n\t\t\t<h3 class=\"ZLzG0d ncoeY E8xBUb\" role=\"heading\" aria-level=\"4\" data-wiz-attrbind=\"aria-level=cvh5g_t\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgIEAA\" data-complete=\"true\" data-processed=\"true\">USP Fysieke Parameters bij Dissolutie: Wat moet u controleren?<!--TgQPHd|||[[2,[null,null,1,null,null,null,null,null,null,null,null,null,[351768,null,0]],[],null,1]]--><\/h3>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgJEAA\" data-complete=\"true\" data-processed=\"true\">Bij het uitvoeren van een dissolutietest draait alles om nauwkeurigheid en reproduceerbaarheid. Een van de belangrijkste pijlers hiervoor is de mechanische kalibratie en de controle van de <span><span jsuid=\"cvh5g_y\" class=\"R78TQ\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KMhGd#Mx1qPe\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><span jsuid=\"cvh5g_z\" data-sfc-cp=\"\" jsaction=\"mouseenter:&amp;cvh5g_z|ZUljYd;mouseleave:&amp;cvh5g_z|aXD3Gb;focusin:&amp;cvh5g_z|Mrjwi;focusout:&amp;cvh5g_z|CXhG2e;pointerdown:&amp;cvh5g_z|wndyDd;click:&amp;cvh5g_z|yrMC6;\" jscontroller=\"H5LVWd#B2zgBd\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\">USP physical parameters<!--TgQPHd|||[[&quot;https:\/\/www.usp.org\/frequently-asked-questions\/reference-standards&quot;,null,[null,null,1,null,null,null,null,null,null,[[1794088069576856,134059268,1863395348],null,null,null,null,[[2,1,10]]],null,null,[244939,null,2],null,null,[{&quot;1218&quot;:[12,null,null,null,[7]]}]],null,null,2,null,null,null,null,0]]--><!--TgQPHd|||[[[null,null,null,null,null,null,[[1794088069576856,134059268,1863395348],null,null,null,null,[[2,1,10]]],&quot;https:\/\/www.usp.org\/frequently-asked-questions\/reference-standards&quot;],0,0],&quot;\\u0026cvh5g_y:u9afN&quot;,&quot;\\u0026cvh5g_y:kEV45c&quot;]--><\/span><!--TgQPHd|||[[&quot;https:\/\/www.usp.org\/frequently-asked-questions\/reference-standards&quot;,null,null,[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,[{&quot;1218&quot;:[12,null,null,null,[7]]}]],12,null,&quot;Reference Standards FAQs | USP&quot;,null,null,&quot;usp.org&quot;,&quot;https:\/\/encrypted-tbn2.gstatic.com\/faviconV2?url\\u003dhttps:\/\/www.usp.org\\u0026client\\u003dAIM\\u0026size\\u003d128\\u0026type\\u003dFAVICON\\u0026fallback_opts\\u003dTYPE,SIZE,URL&quot;,[[1794088069576856,134059268,1863395348],null,null,null,null,[[2,1,10]]],null,&quot;6c49a0d1-660a-40ef-b78f-e002ae8d66b9&quot;]]--><\/span><\/span> (fysieke parameters). Als deze parameters buiten de specificaties vallen, kan dit de hydrodynamicamix in het vat veranderen, wat direct leidt tot foutieve of niet-reproduceerbare testresultaten.<!--TgQPHd|||[]--><\/div>\n<div data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgJEAA\" data-complete=\"true\" data-processed=\"true\"><\/div>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgMEAA\" data-complete=\"true\" data-processed=\"true\">Of u nu werkt met een Pharmatest USP\/EP Apparaat 1 (manden) of Apparaat 2 (paddles), de volgende fysieke parameters moet u strikt en regelmatig controleren.<!--TgQPHd|||[]--><\/div>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<hr class=\"s6NV4e\" data-sfc-root=\"c\" data-sfc-pl=\"|||[]\" data-complete=\"true\" data-processed=\"true\" data-sae=\"\" \/>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<h3 class=\"ZLzG0d ncoeY E8xBUb\" role=\"heading\" aria-level=\"4\" data-wiz-attrbind=\"aria-level=cvh5g_15\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgOEAA\" data-complete=\"true\" data-processed=\"true\">1. Centrering van de as (Wobble)<!--TgQPHd|||[[2,[null,null,1,null,null,null,null,null,null,null,null,null,[351768,null,0]],[],null,1]]--><\/h3>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgPEAA\" data-complete=\"true\" data-processed=\"true\">De as (shaft) moet perfect recht draaien. Als een as wiebelt of wobblet, cre\u00ebert dit ongewenste turbulentie in het dissolutiemedium, wat de oplossnelheid kunstmatig kan versnellen.<!--TgQPHd|||[]--><\/div>\n<ul class=\"XSq4R KI3fJ\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgQEAA\" data-complete=\"true\" data-processed=\"true\">\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgQEAE\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_19\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">Wat te controleren:<!--TgQPHd|||[]--><\/strong> De uitslag (wobble) van de draaiende as en de mand\/paddle.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgQEAI\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_1c\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">USP-limiet:<!--TgQPHd|||[]--><\/strong> Maximaal <strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">2,0 mm<!--TgQPHd|||[]--><\/strong> totale uitslag (run-out) over een volledige rotatie, gemeten op de voorgeschreven punten.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<p><!--TgQPHd|||[]--><\/ul>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<h3 class=\"ZLzG0d ncoeY E8xBUb\" role=\"heading\" aria-level=\"4\" data-wiz-attrbind=\"aria-level=cvh5g_1g\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgREAA\" data-complete=\"true\" data-processed=\"true\">2. Centrering van de as in de vessel (Vessel Centering)<!--TgQPHd|||[[2,[null,null,1,null,null,null,null,null,null,null,null,null,[351768,null,0]],[],null,1]]--><\/h3>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgSEAA\" data-complete=\"true\" data-processed=\"true\">De as moet exact in het geometrische midden van de dissolutie-vessel hangen. Een as die te dicht bij de vessel wand staat, verandert de vloeistofdynamiek drastisch.<!--TgQPHd|||[]--><\/div>\n<ul class=\"XSq4R KI3fJ\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgTEAA\" data-complete=\"true\" data-processed=\"true\">\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgTEAE\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_1k\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">Wat te controleren:<!--TgQPHd|||[]--><\/strong> De afstand van de as tot de binnenwand van het vat op verschillende punten.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgTEAI\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_1n\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">USP-limiet:<!--TgQPHd|||[]--><\/strong> De as mag maximaal <strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">2,0 mm<!--TgQPHd|||[]--><\/strong> afwijken van het exacte midden van het vat.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<p><!--TgQPHd|||[]--><\/ul>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<h3 class=\"ZLzG0d ncoeY E8xBUb\" role=\"heading\" aria-level=\"4\" data-wiz-attrbind=\"aria-level=cvh5g_1r\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgUEAA\" data-complete=\"true\" data-processed=\"true\">3. Verticaliteit van de as en de vessel (Verticality \/ Alignment)<!--TgQPHd|||[[2,[null,null,1,null,null,null,null,null,null,null,null,null,[351768,null,0]],[],null,1]]--><\/h3>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgVEAA\" data-complete=\"true\" data-processed=\"true\">Zowel de assen als de vessels zelf moeten perfect loodrecht staan ten opzichte van de basisplaat.<!--TgQPHd|||[]--><\/div>\n<ul class=\"XSq4R KI3fJ\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgWEAA\" data-complete=\"true\" data-processed=\"true\">\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgWEAE\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_1v\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">Wat te controleren:<!--TgQPHd|||[]--><\/strong> De hoek van de assen en de vaten met behulp van een nauwkeurige digitale waterpas.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgWEAI\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_1y\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">USP-limiet:<!--TgQPHd|||[]--><\/strong> De afwijking mag niet meer zijn dan <strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">0,5\u00b0<!--TgQPHd|||[]--><\/strong> van de verticale as.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<p><!--TgQPHd|||[]--><\/ul>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<h3 class=\"ZLzG0d ncoeY E8xBUb\" role=\"heading\" aria-level=\"4\" data-wiz-attrbind=\"aria-level=cvh5g_22\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgXEAA\" data-complete=\"true\" data-processed=\"true\">4. Hoogte van de paddle of mand (Clutch Height \/ Tool Height)<!--TgQPHd|||[[2,[null,null,1,null,null,null,null,null,null,null,null,null,[351768,null,0]],[],null,1]]--><\/h3>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgYEAA\" data-complete=\"true\" data-processed=\"true\">De afstand tussen de onderkant van de paddle of basket en de bodem van de vessel\u00a0 is cruciaal voor de stroming onder het doseervormpje.<!--TgQPHd|||[]--><\/div>\n<ul class=\"XSq4R KI3fJ\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgZEAA\" data-complete=\"true\" data-processed=\"true\">\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgZEAE\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_26\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">Wat te controleren:<!--TgQPHd|||[]--><\/strong> De exacte afstand van de onderzijde van het roerelement tot de binnenbodem van het vat.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgZEAI\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_29\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">\u00a0 USP-limiet:<!--TgQPHd|||[]--><\/strong> Moet exact <strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" aria-owns=\"action-menu-parent-container\">25 mm \u00b1 2 mm <\/strong><\/span><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_29\" data-complete=\"true\">zijn.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<p><!--TgQPHd|||[]--><\/ul>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<h3 class=\"ZLzG0d ncoeY E8xBUb\" role=\"heading\" aria-level=\"4\" data-wiz-attrbind=\"aria-level=cvh5g_2d\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgaEAA\" data-complete=\"true\" data-processed=\"true\">5. Rotatiesnelheid (RPM \/ Rotational Speed)<!--TgQPHd|||[[2,[null,null,1,null,null,null,null,null,null,null,null,null,[351768,null,0]],[],null,1]]--><\/h3>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgbEAA\" data-complete=\"true\" data-processed=\"true\">De snelheid waarmee de paddles of baskets draaien, bepaalt de mechanische energie die aan het medium wordt afgegeven.<!--TgQPHd|||[]--><\/div>\n<ul class=\"XSq4R KI3fJ\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgcEAA\" data-complete=\"true\" data-processed=\"true\">\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgcEAE\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_2h\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">Wat te controleren:<!--TgQPHd|||[]--><\/strong> De werkelijke draaisnelheid van de assen met een gecertificeerde tachometer.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgcEAI\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_2k\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">USP-limiet:<!--TgQPHd|||[]--><\/strong> De snelheid moet binnen <strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">\u00b1 4%<!--TgQPHd|||[]--><\/strong> van de ingestelde waarde liggen (bijvoorbeeld tussen 48 en 52 RPM bij een instelling van 50 RPM).<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<p><!--TgQPHd|||[]--><\/ul>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<h3 class=\"ZLzG0d ncoeY E8xBUb\" role=\"heading\" aria-level=\"4\" data-wiz-attrbind=\"aria-level=cvh5g_2o\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgdEAA\" data-complete=\"true\" data-processed=\"true\">6. Temperatuur van het medium<!--TgQPHd|||[[2,[null,null,1,null,null,null,null,null,null,null,null,null,[351768,null,0]],[],null,1]]--><\/h3>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgeEAA\" data-complete=\"true\" data-processed=\"true\">De oplosbaarheid van een actieve stof is sterk afhankelijk van de temperatuur.<!--TgQPHd|||[]--><\/div>\n<ul class=\"XSq4R KI3fJ\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgfEAA\" data-complete=\"true\" data-processed=\"true\">\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgfEAE\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_2s\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">Wat te controleren:<!--TgQPHd|||[]--><\/strong> De temperatuur in elk afzonderlijk vat v\u00f3\u00f3r en tijdens de test.<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<li class=\"Z1qcYe\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgfEAI\" data-complete=\"true\" data-sae=\"\"><span class=\"iNqyIf\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KdQfFc#d5Qebf\" data-sfc-root=\"c\" jsuid=\"cvh5g_2v\" data-complete=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">USP-limiet:<!--TgQPHd|||[]--><\/strong> Het medium moet stabiel op <strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\">37 \u00b0C \u00b1 0,5 \u00b0C<!--TgQPHd|||[]--><\/strong> gehouden worden (tenzij anders vermeld in de monografie).<!--TgQPHd|||[]--><\/span><!--TgQPHd|||[]--><\/li>\n<p><!--TgQPHd|||[]--><\/ul>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<h3 class=\"ZLzG0d ncoeY E8xBUb\" role=\"heading\" aria-level=\"4\" data-wiz-attrbind=\"aria-level=cvh5g_2z\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQggEAA\" data-complete=\"true\" data-processed=\"true\">7. Kwaliteit en staat van de vaten (Vessel Integrity)<!--TgQPHd|||[[2,[null,null,1,null,null,null,null,null,null,null,null,null,[351768,null,0]],[],null,1]]--><\/h3>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQghEAA\" data-complete=\"true\" data-processed=\"true\">Krassen, imperfecties of vervormingen in het glas van het vat kunnen de hydrodynamica be\u00efnvloeden. Daarnaast moeten de vaten schoon en vrij van residu zijn.<!--TgQPHd|||[]--><\/div>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<hr class=\"s6NV4e\" data-sfc-root=\"c\" data-sfc-pl=\"|||[]\" data-complete=\"true\" data-processed=\"true\" data-sae=\"\" \/>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<h3 class=\"ZLzG0d ncoeY E8xBUb\" role=\"heading\" aria-level=\"4\" data-wiz-attrbind=\"aria-level=cvh5g_34\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgjEAA\" data-complete=\"true\" data-processed=\"true\">Waarom is de controle van Pharmatest-apparatuur zo effici\u00ebnt?<!--TgQPHd|||[[2,[null,null,1,null,null,null,null,null,null,null,null,null,[351768,null,0]],[],null,1]]--><\/h3>\n<div role=\"heading\" aria-level=\"4\" data-animation-nesting=\"\" data-sfc-cp=\"\" data-wiz-attrbind=\"aria-level=cvh5g_34\/fLk2Md\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgjEAA\" data-complete=\"true\" data-processed=\"true\" data-sae=\"\"><\/div>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgkEAA\" data-complete=\"true\" data-processed=\"true\">Moderne dissolutietesters van <span><span jsuid=\"cvh5g_3b\" class=\"R78TQ\" data-sfc-cp=\"\" jsaction=\"\" jscontroller=\"KMhGd#Mx1qPe\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\"><span jsuid=\"cvh5g_3c\" data-sfc-cp=\"\" jsaction=\"mouseenter:&amp;cvh5g_3c|ZUljYd;mouseleave:&amp;cvh5g_3c|aXD3Gb;focusin:&amp;cvh5g_3c|Mrjwi;focusout:&amp;cvh5g_3c|CXhG2e;pointerdown:&amp;cvh5g_3c|wndyDd;click:&amp;cvh5g_3c|yrMC6;\" jscontroller=\"H5LVWd#B2zgBd\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\">Pharmatest<!--TgQPHd|||[[[null,null,null,null,null,null,[[1794088069576856,134059268,1863395348],null,null,null,null,[[2,1,37]]],&quot;https:\/\/pharmatest.com\/&quot;],0,0],&quot;\\u0026cvh5g_3b:u9afN&quot;,&quot;\\u0026cvh5g_3b:kEV45c&quot;]--><\/span><!--TgQPHd|||[[&quot;https:\/\/pharmatest.com\/&quot;,null,null,[null,null,null,null,null,null,null,null,null,null,null,null,null,null,null,[{&quot;1218&quot;:[12,null,null,null,[7]]}]],12,null,&quot;Pharmatest Services: Home&quot;,null,null,&quot;pharmatest.com&quot;,&quot;https:\/\/encrypted-tbn2.gstatic.com\/faviconV2?url\\u003dhttps:\/\/pharmatest.com\\u0026client\\u003dAIM\\u0026size\\u003d128\\u0026type\\u003dFAVICON\\u0026fallback_opts\\u003dTYPE,SIZE,URL&quot;,[[1794088069576856,134059268,1863395348],null,null,null,null,[[2,1,37]]],null,&quot;b74e1cdb-22de-4e77-a2f5-65f9e68006cc&quot;]]--><\/span><\/span> zijn ontworpen om aan de strengste <span><span jsuid=\"cvh5g_38\" jsaction=\"\" jscontroller=\"js7F5#wEAOaf\" data-sfc-root=\"c\" data-wiz-uids=\"cvh5g_39\" data-ved=\"2ahUKEwiY8dTw6vaXAxUElf0HHRQoEW8QrsMTeggIAggBCCQQAg\" data-complete=\"true\" data-processed=\"true\"><!--qkimaf cvh5g_38\/WyzG9e--><span class=\"\" data-processed=\"true\">USP- en EP-richtlijnen<\/span><!--cqw1tb cvh5g_38\/WyzG9e--><!--TgQPHd|||[[&quot;USP- en EP-richtlijnen&quot;,&quot;ee54db742aff882a&quot;,&quot;&quot;,&quot;&quot;,&quot;&quot;]]--><\/span><\/span> te voldoen. Dankzij geavanceerde functies zoals gecentreerde vatbevestigingen en zelf-uitlijnende assen wordt de kans op mechanische afwijkingen geminimaliseerd.<!--TgQPHd|||[]--><\/div>\n<div data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgkEAA\" data-complete=\"true\" data-processed=\"true\"><\/div>\n<div class=\"yhAwj\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\" data-sfc-inited=\"2\"><!--TgQPHd|||[]--><\/div>\n<div class=\"n6owBd awi2gc\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-hveid=\"CAIIAQgnEAA\" data-complete=\"true\" data-processed=\"true\"><strong class=\"rQesXe MPyX\" data-sfc-cp=\"\" data-sfc-root=\"c\" data-complete=\"true\" data-processed=\"true\">De gouden regel:<!--TgQPHd|||[]--><\/strong> Voer periodiek een mechanische kalibratie (MQ) uit en controleer de kritische parameters visueel v\u00f3\u00f3r elke run. Hiermee garandeert u de betrouwbaarheid van uw data en voorkomt u kostbare Out-of-Specification (OOS) onderzoeken.<\/div>\n<p>Bron: <a href=\"https:\/\/www.prolyse.nl\/pharmaceutical-physical-testing-equipment\/usp-physical-parameters-wat-moet-u-controleren\/\">https:\/\/www.prolyse.nl\/pharmaceutical-physical-testing-equipment\/usp-physical-parameters-wat-moet-u-controleren\/<\/a><\/p>\t\t<\/div>\n\t<\/div>\n<\/div>\r\n\t<div class=\"articles bg--offwhite automatic\">\r\n\t\t<div class=\"container\">\r\n\t\t\t<div class=\"articles__header\">\r\n\t\t\t\t\t\t\t\t\t<div class='heading-wrapper'><svg width=\"13\" height=\"13\" viewBox=\"0 0 13 13\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"6.394\" cy=\"6.5\" r=\"6.394\" fill=\"#000\"\/><\/svg><h2>Gerelateerde artikelen<\/h2><\/div>\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"\/profiel\/prolyse-b-v\/\" class=\"button button--outline\">Bekijk profiel<\/a>\r\n\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t<div class=\"post-grid post-grid--no-padding\">\r\n\t\t\t\t\n<a class=\"single-item single-item__articles\" href=\"https:\/\/fhi.nl\/en\/news\/medische-20w-dc-dc-converter\/\" data-id=\"43803\">\n\t<div class=\"single-item__articles-icon\">\n\t\t<svg width=\"35\" height=\"35\" viewBox=\"0 0 35 35\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n<mask id=\"mask0_1182_5532\" style=\"mask-type:luminance\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"35\" height=\"35\">\n<path d=\"M0 0H35V35H0V0Z\" fill=\"white\"\/>\n<\/mask>\n<g mask=\"url(#mask0_1182_5532)\">\n<path d=\"M5.12695 9.22852H1.02539V31.9238H10.4299C12.2868 31.9238 14.0678 32.6615 15.3809 33.9746H19.6191C20.9322 32.6615 22.7132 31.9238 24.5701 31.9238H33.9746V11.2793H29.873\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M17.5 9.22852H18.1426C20.0088 7.89544 22.2237 7.17773 24.5615 7.17773H29.873V27.8223H24.5615C22.2237 27.8223 20.0088 28.54 18.1426 29.873H16.8574C14.9912 28.54 12.7763 27.8223 10.4385 27.8223H5.12695V5.12695H9.22852\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M9.22852 1.02539V21.6699C13.759 21.6699 17.5 25.3425 17.5 29.873V9.22852C17.5 4.698 13.759 1.02539 9.22852 1.02539Z\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<\/g>\n<\/svg>\n\t<\/div>\n\t<div class=\"single-item__articles-title\"><div class='heading-wrapper'><h3>Medische 20W DC\/DC converter<\/h3><\/div><\/div>\n\t<div class=\"single-item__articles-terms\">\n\t\t\n\t\t\n\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Leden content<\/span>\n\t\t\t\t\t<\/div>\n\t<div class=\"single-item__articles-author-date-wrapper\">\n\t\t\t\t\t<div class=\"single-item__articles-author\">\n\t\t\t\tElincom Electronics B.V.\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"single-item__articles-date\">\n\t\t\t\t14 August 2019\t\t\t<\/div>\n\t\t\t<\/div>\n<\/a>\n\n<a class=\"single-item single-item__articles\" href=\"https:\/\/fhi.nl\/en\/news\/fs-feup-from-pcb-breakthroughs-to-racing-success\/\" data-id=\"72018\">\n\t<div class=\"single-item__articles-icon\">\n\t\t<svg width=\"103\" height=\"103\" viewBox=\"0 0 103 103\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n<path fill-rule=\"evenodd\" clip-rule=\"evenodd\" d=\"M49.5 98.9587V82.3076C33.3844 81.2758 20.6328 67.878 20.6328 51.5019C20.6328 35.1258 33.3844 21.728 49.5 20.6962V4.04134C24.1941 5.08952 4 25.9365 4 51.5C4 77.0635 24.1941 97.9105 49.5 98.9587ZM53.5 78.2983V61.8096H76.3238C72.5238 70.9498 63.8222 77.5397 53.5 78.2983ZM49.5 78.298V61.8096H26.681C30.4804 70.9484 39.1799 77.5377 49.5 78.298ZM47.0728 57.8096H25.3773C24.8906 55.7865 24.6328 53.6743 24.6328 51.5019C24.6328 37.3358 35.5955 25.7301 49.5 24.7058V37.013H34.0466C33.2709 37.013 32.5653 37.4615 32.2359 38.1637C31.9065 38.8659 32.0128 39.6952 32.5086 40.2916L47.0728 57.8096ZM55.9249 57.8096H77.6274C78.1141 55.7865 78.3719 53.6743 78.3719 51.5019C78.3719 37.3342 67.4068 25.7275 53.5 24.7055V37.013H68.9511C69.7268 37.013 70.4324 37.4615 70.7618 38.1637C71.0912 38.8659 70.9849 39.6952 70.4891 40.2916L55.9249 57.8096ZM53.5 82.3079V98.9587C78.8059 97.9105 99 77.0635 99 51.5C99 25.9365 78.8059 5.08952 53.5 4.04134V20.6959C69.6178 21.7254 82.3719 35.1242 82.3719 51.5019C82.3719 67.8796 69.6178 81.2784 53.5 82.3079ZM0 51.5C0 23.7271 21.9843 1.08883 49.5 0.0381213V0H51.5H53.5V0.0381213C81.0157 1.08883 103 23.7271 103 51.5C103 79.9427 79.9427 103 51.5 103C23.0573 103 0 79.9427 0 51.5ZM38.3102 41.013H64.6875L51.4989 56.8765L38.3102 41.013Z\" fill=\"#2DD881\"\/>\n<\/svg>\n\t<\/div>\n\t<div class=\"single-item__articles-title\"><div class='heading-wrapper'><h3>FS FEUP: From PCB Breakthroughs to Racing Success<\/h3><\/div><\/div>\n\t<div class=\"single-item__articles-terms\">\n\t\t\n\t\t\n\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Industri\u00eble Elektronica<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Design Automation &amp; Embedded Systems Event<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Leden content<\/span>\n\t\t\t\t\t<\/div>\n\t<div class=\"single-item__articles-author-date-wrapper\">\n\t\t\t\t\t<div class=\"single-item__articles-author\">\n\t\t\t\tEurocircuits N.V.\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"single-item__articles-date\">\n\t\t\t\t22 August 2025\t\t\t<\/div>\n\t\t\t<\/div>\n<\/a>\n\n<a class=\"single-item single-item__articles\" href=\"https:\/\/fhi.nl\/en\/news\/nieuwsbrief-juni-2022\/\" data-id=\"35598\">\n\t<div class=\"single-item__articles-icon\">\n\t\t<svg width=\"35\" height=\"35\" viewBox=\"0 0 35 35\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\">\n<mask id=\"mask0_1182_5532\" style=\"mask-type:luminance\" maskUnits=\"userSpaceOnUse\" x=\"0\" y=\"0\" width=\"35\" height=\"35\">\n<path d=\"M0 0H35V35H0V0Z\" fill=\"white\"\/>\n<\/mask>\n<g mask=\"url(#mask0_1182_5532)\">\n<path d=\"M5.12695 9.22852H1.02539V31.9238H10.4299C12.2868 31.9238 14.0678 32.6615 15.3809 33.9746H19.6191C20.9322 32.6615 22.7132 31.9238 24.5701 31.9238H33.9746V11.2793H29.873\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M17.5 9.22852H18.1426C20.0088 7.89544 22.2237 7.17773 24.5615 7.17773H29.873V27.8223H24.5615C22.2237 27.8223 20.0088 28.54 18.1426 29.873H16.8574C14.9912 28.54 12.7763 27.8223 10.4385 27.8223H5.12695V5.12695H9.22852\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<path d=\"M9.22852 1.02539V21.6699C13.759 21.6699 17.5 25.3425 17.5 29.873V9.22852C17.5 4.698 13.759 1.02539 9.22852 1.02539Z\" stroke=\"#2A5CEE\" stroke-width=\"2\" stroke-miterlimit=\"10\"\/>\n<\/g>\n<\/svg>\n\t<\/div>\n\t<div class=\"single-item__articles-title\"><div class='heading-wrapper'><h3>Nieuwsbrief juni 2022<\/h3><\/div><\/div>\n\t<div class=\"single-item__articles-terms\">\n\t\t\n\t\t\n\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">EMVT<\/span>\n\t\t\t\t\t\t\t\t<span class=\"button button--outline single-item__articles-term--branche single-item__articles-term\">Leden content<\/span>\n\t\t\t\t\t<\/div>\n\t<div class=\"single-item__articles-author-date-wrapper\">\n\t\t\t\t\t<div class=\"single-item__articles-author\">\n\t\t\t\tVereniging EMVT\t\t\t<\/div>\n\t\t\t\t\t\t\t<div class=\"single-item__articles-date\">\n\t\t\t\t22 June 2022\t\t\t<\/div>\n\t\t\t<\/div>\n<\/a>\n\t\t\t<\/div>\r\n\t\t<\/div>\r\n\t<\/div>\r\n\r\n","protected":false},"excerpt":{"rendered":"","protected":false},"featured_media":0,"template":"","branches":[],"events":[],"secretariat":[],"categories":[],"themes_tax":[],"content_types":[],"class_list":["post-90922","news","type-news","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>USP Physical Parameters: wat moet u controleren? - FHI, Federatie van technologiebranches<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhi.nl\/en\/nieuws\/usp-physical-parameters-wat-moet-u-controleren\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"USP Physical 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