{"id":60893,"date":"2024-12-12T15:56:08","date_gmt":"2024-12-12T14:56:08","guid":{"rendered":"https:\/\/fhi.nl\/?page_id=60893"},"modified":"2024-12-12T15:56:12","modified_gmt":"2024-12-12T14:56:12","slug":"salivary-gland-organoids-to-treat-radiotherapy-induced-xerostomia","status":"publish","type":"page","link":"https:\/\/fhi.nl\/en\/lifescience\/salivary-gland-organoids-to-treat-radiotherapy-induced-xerostomia\/","title":{"rendered":"Salivary gland organoids to treat radiotherapy \u2013 induced xerostomia"},"content":{"rendered":"<header id=\"header\" class=\"header header--high header--branch\">\n\n\t\t\t\t\t\t\t\t\t\t<div class=\"header__background header__background--high\">\n\t\t\t\t\t<img decoding=\"async\" class=\"header__background-image\" src=\"https:\/\/fhi.nl\/app\/uploads\/2024\/12\/Foto-Life-Science-banners-1617x1080.jpg\" alt=\"\">\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\n\t\n\t<div class=\"container\">\n\t\t<div class=\"header__content\">\n\t\t\t<div class=\"header__first\">\n\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<h6 class=\"header__subtitle\">Rob P. Coppes, the University Medical Center Groningen (UMCG)<\/h6>\n\t\t\t\t\n\t\t\t\t<h1 class=\"header__title\" >\n\t\t\t\t\tSalivary gland organoids to treat radiotherapy \u2013 induced xerostomia\t\t\t\t<\/h1>\n\n\t\t\t\t<div class=\"header__dots-line\">\n\t\t\t\t\t<svg width=\"431\" height=\"9\" viewbox=\"0 0 431 9\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M430.799 4.192a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.135 1.135 0 1 1-2.27 0 1.135 1.135 0 0 1 2.27 0Zm-27.27 0a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.39 1.39 0 1 1-2.78 0 1.39 1.39 0 0 1 2.78 0Zm-27.78 0a1.645 1.645 0 1 1-3.29 0 1.645 1.645 0 0 1 3.29 0Zm-28.29 0a1.9 1.9 0 1 1-3.799 0 1.9 1.9 0 0 1 3.799 0Zm-28.799 0a2.154 2.154 0 1 1-4.308 0 2.154 2.154 0 0 1 4.308 0Zm-29.308 0a2.41 2.41 0 1 1-4.819 0 2.41 2.41 0 0 1 4.819 0Zm-29.819 0a2.663 2.663 0 1 1-5.326.001 2.663 2.663 0 0 1 5.326-.001Zm-30.327 0a2.919 2.919 0 1 1-5.837 0 2.919 2.919 0 0 1 5.837 0Zm-30.837 0a3.173 3.173 0 1 1-6.345.001 3.173 3.173 0 0 1 6.345 0Zm-31.346 0a3.428 3.428 0 1 1-6.856 0 3.428 3.428 0 0 1 6.856 0Zm-31.856 0a3.683 3.683 0 1 1-7.365 0 3.683 3.683 0 0 1 7.365 0Zm-32.365 0a3.937 3.937 0 1 1-7.875 0 3.937 3.937 0 0 1 7.875 0Zm-32.874 0a4.192 4.192 0 1 1-8.384 0 4.192 4.192 0 0 1 8.384 0Z\" fill=\"#FFF960\"\/><\/svg>\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"header__description\">\n\t\t\t\t\t\t\t<p>February 13th, FHI Leusden<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"header__second\">\n\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"header__branch-logos\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/fhi.nl\/app\/uploads\/2024\/02\/Laboratorium-technologie.svg\" class=\"header__branch-logo\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<a class=\"header__button button\" target=\"_blank\" href=\"https:\/\/events.fhi.nl\/lifescience-2025\">\n\t\t\t\t\t\t\tMore information\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/header>\n\n\t<div class=\"header__meta\">\n\t<div class=\"container\">\n\t\t<div class=\"header__meta__category\">\n\n\t\t\t\t\t\t\t<div class=\"header__meta__detail\">\n\t\t\t\t\t<div>Branch<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_branches_kennishub=laboratorium-technologie\" class=\"header__meta__detail--branch\">\n\t\t\t\t\t\t\t\tLaboratory Technology\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<div class=\"text bg--offwhite\">\n\t<div class=\"container\">\n\t\t\t\t\t<div class='heading-wrapper'><svg width=\"13\" height=\"13\" viewbox=\"0 0 13 13\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"6.394\" cy=\"6.5\" r=\"6.394\" fill=\"#000\"\/><\/svg><h2>09.30 \u2013 10.15<\/h2><\/div>\t\t\t\t\t\t<div class=\"text__content text__content--1-col\">\n\t\t\t<p>Severe hyposalivation and consequential xerostomia (dry mouth syndrome) are common, often irreversible side effects of radiotherapy treatment for head-and-neck cancer. Xerostomia severely hampers the quality of affected patients&#039; lives. Currently, no successful treatment exists. The aim was to develop a stem cell therapy to treat radiation-induced hyposalivation.<\/p>\n<p>First, we developed methods to culture murine and patient-specific tissue resembling salivary gland-derived organoids (SGO). These SGOs contain all the glandular lineages and can extensively self-renew and rescue salivary gland function upon (xeno-)transplantation. Subsequently, we developed a GMP-compliant protocol for isolating and expanding human-derived salivary gland organoids derived from patient submandibular gland biopsies taken before radiotherapy treatment with an efficiency comparable to current non-GMP research-based protocols. The functionality of salivary gland-derived cells is maintained after cryopreservation, allowing the protocol to be adapted to the patient&#039;s radiotherapy treatment schedule. This presentation will show the developmental path to the first in human application of autologous organoid-derived cell transplantation in head and neck cancer patients. The first preliminary results will be presented.<\/p>\n<p>Supported by the Dutch Cancer Society (KWF) and The Netherlands Organization for Health Research and Development (ZonMw).<\/p>\n<p><em>Speaker: Rob P. Coppes, the University Medical Center Groningen (UMCG)<\/em><\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":41,"featured_media":0,"parent":22172,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"branches":[14],"events":[369],"secretariat":[],"categories":[],"themes_tax":[],"class_list":["post-60893","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Salivary gland organoids to treat radiotherapy - induced xerostomia - FHI, federatie van technologiebranches<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/fhi.nl\/en\/lifescience\/salivary-gland-organoids-to-treat-radiotherapy-induced-xerostomia\/\" \/>\n<meta property=\"og:locale\" content=\"en_GB\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Salivary gland organoids to treat radiotherapy - induced xerostomia - FHI, federatie van technologiebranches\" \/>\n<meta property=\"og:url\" content=\"https:\/\/fhi.nl\/en\/lifescience\/salivary-gland-organoids-to-treat-radiotherapy-induced-xerostomia\/\" \/>\n<meta property=\"og:site_name\" content=\"FHI, federatie van technologiebranches\" \/>\n<meta property=\"article:modified_time\" content=\"2024-12-12T14:56:12+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Estimated reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"1 minute\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/fhi.nl\/lifescience\/salivary-gland-organoids-to-treat-radiotherapy-induced-xerostomia\/\",\"url\":\"https:\/\/fhi.nl\/lifescience\/salivary-gland-organoids-to-treat-radiotherapy-induced-xerostomia\/\",\"name\":\"Salivary gland organoids to treat radiotherapy - induced xerostomia - FHI, federatie van technologiebranches\",\"isPartOf\":{\"@id\":\"https:\/\/fhi.nl\/#website\"},\"datePublished\":\"2024-12-12T14:56:08+00:00\",\"dateModified\":\"2024-12-12T14:56:12+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/fhi.nl\/lifescience\/salivary-gland-organoids-to-treat-radiotherapy-induced-xerostomia\/#breadcrumb\"},\"inLanguage\":\"en-GB\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/fhi.nl\/lifescience\/salivary-gland-organoids-to-treat-radiotherapy-induced-xerostomia\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/fhi.nl\/lifescience\/salivary-gland-organoids-to-treat-radiotherapy-induced-xerostomia\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/fhi.nl\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Life Science\",\"item\":\"https:\/\/fhi.nl\/lifescience\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Salivary gland organoids to treat radiotherapy &#8211; 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