{"id":80016,"date":"2026-03-16T11:46:51","date_gmt":"2026-03-16T10:46:51","guid":{"rendered":"https:\/\/fhi.nl\/?page_id=80016"},"modified":"2026-03-19T10:29:29","modified_gmt":"2026-03-19T09:29:29","slug":"carta-bringing-human-tissue-models-closer-to-routine-via-scalable-readouts","status":"publish","type":"page","link":"https:\/\/fhi.nl\/en\/carta-bringing-human-tissue-models-closer-to-routine-via-scalable-readouts\/","title":{"rendered":"Measuring what matters: Patient-specific functional assays for vascular disease"},"content":{"rendered":"<header id=\"header\" class=\"header header--high header--branch\">\n\n\t\n\t\n\t<div class=\"container\">\n\t\t<div class=\"header__content\">\n\t\t\t<div class=\"header__first\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"header__navigation-button\">\n\t\t\t\t\t\t<a class=\"header__navigation-button__arrow\" target=\"_self\" href=\"https:\/\/fhi.nl\/en\/lifescience\/programma\/\">\n\t\t\t\t\t\t\t<svg width=\"56\" height=\"33\" viewbox=\"0 0 56 33\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><rect x=\"56\" y=\"33\" width=\"56\" height=\"33\" rx=\"16.5\" transform=\"rotate(180 56 33)\" fill=\"#ffda56\"\/><path d=\"M22.262 22.456 16.294 16.5l5.968-5.956M39.706 16.5H16.293\" stroke=\"#fff\" stroke-width=\"2\" stroke-linecap=\"round\"\/><\/svg> To program\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<h1 class=\"header__title\" >\n\t\t\t\t\tMeasuring what matters: Patient-specific functional assays for vascular disease\t\t\t\t<\/h1>\n\n\t\t\t\t<div class=\"header__dots-line\">\n\t\t\t\t\t<svg width=\"431\" height=\"9\" viewbox=\"0 0 431 9\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M430.799 4.192a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.135 1.135 0 1 1-2.27 0 1.135 1.135 0 0 1 2.27 0Zm-27.27 0a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.39 1.39 0 1 1-2.78 0 1.39 1.39 0 0 1 2.78 0Zm-27.78 0a1.645 1.645 0 1 1-3.29 0 1.645 1.645 0 0 1 3.29 0Zm-28.29 0a1.9 1.9 0 1 1-3.799 0 1.9 1.9 0 0 1 3.799 0Zm-28.799 0a2.154 2.154 0 1 1-4.308 0 2.154 2.154 0 0 1 4.308 0Zm-29.308 0a2.41 2.41 0 1 1-4.819 0 2.41 2.41 0 0 1 4.819 0Zm-29.819 0a2.663 2.663 0 1 1-5.326.001 2.663 2.663 0 0 1 5.326-.001Zm-30.327 0a2.919 2.919 0 1 1-5.837 0 2.919 2.919 0 0 1 5.837 0Zm-30.837 0a3.173 3.173 0 1 1-6.345.001 3.173 3.173 0 0 1 6.345 0Zm-31.346 0a3.428 3.428 0 1 1-6.856 0 3.428 3.428 0 0 1 6.856 0Zm-31.856 0a3.683 3.683 0 1 1-7.365 0 3.683 3.683 0 0 1 7.365 0Zm-32.365 0a3.937 3.937 0 1 1-7.875 0 3.937 3.937 0 0 1 7.875 0Zm-32.874 0a4.192 4.192 0 1 1-8.384 0 4.192 4.192 0 0 1 8.384 0Z\" fill=\"#FFF960\"\/><\/svg>\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"header__description\">\n\t\t\t\t\t\t\t<p>Dr. ir. Koen Reesink<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"header__second\">\n\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"header__branch-logos\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/fhi.nl\/app\/uploads\/2024\/02\/Laboratorium-technologie.svg\" class=\"header__branch-logo\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/header>\n\n\t<div class=\"header__meta\">\n\t<div class=\"container\">\n\t\t<div class=\"header__meta__category\">\n\n\t\t\t\t\t\t\t<div class=\"header__meta__detail\">\n\t\t\t\t\t<div>Branch<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_branches_kennishub=laboratorium-technologie\" class=\"header__meta__detail--branch\">\n\t\t\t\t\t\t\t\tLaboratory Technology\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\t\t\t\t<div class=\"header__meta__detail\">\n\t\t\t\t\t<div>Subject<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_onderwerp_kennishub=laboratorium-technologie\" class=\"header__meta__detail--categorie\">\n\t\t\t\t\t\t\t\tLaboratory Technology\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_onderwerp_kennishub=life-science-biotechnologie\" class=\"header__meta__detail--categorie\">\n\t\t\t\t\t\t\t\tLife Science\/Biotechnology\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<div class=\"text bg--offwhite\">\n\t<div class=\"container\">\n\t\t\t\t\t<div class='heading-wrapper'><svg width=\"13\" height=\"13\" viewbox=\"0 0 13 13\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"6.394\" cy=\"6.5\" r=\"6.394\" fill=\"#000\"\/><\/svg><h2>10:30 \u2013 11:00<\/h2><\/div>\t\t\t\t\t\t<div class=\"text__content text__content--1-col\">\n\t\t\t<p>Across biomedical research, we increasingly recognize that understanding disease requires measuring function in human cells\u2014not only molecular signatures. In CELLSYSTEMICS, we therefore developed a human measurement platform that combines standardized hiPSC differentiation, engineered vascular tissues, and quantitative functional readouts. From a simple blood sample, we generate patient-specific vascular muscle constructs whose contractility and drug response can be assessed in real time.<\/p>\n<p>In the follow-up CARTA project, we are advancing the existing Cuore platform into a patient-specific assay to diagnose vascular smooth muscle cell dysfunction and enable in vitro screening of therapeutic options. Today I will show how integrating standardized media and scalable structure\u2013function readouts brings human tissue models closer to routine use in research and personalized medicine.<\/p>\n<p>\u2013 Koen Reesink \u2013<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n<div class=\"image bg--white\">\n\t<div class=\"container\">\t\t\t<div class='heading-wrapper'><svg width=\"13\" height=\"13\" viewbox=\"0 0 13 13\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"6.394\" cy=\"6.5\" r=\"6.394\" fill=\"#000\"\/><\/svg><h2>Featured article<\/h2><\/div>\t\t<div class=\"image__wrapper\">\n\n\t\t\n\t\t\t\t\t<div class=\"image__content\">\n\t\t\t\t\t\t\t\t\t<div class=\"image__titles\">\n\t\t\t\t\t\t<div class='heading-wrapper'><h2 class='image__title'>Living with a ticking time bomb<\/h2><\/div>\t\t\t\t\t\t\t\t\t\t\t\t\t<span class=\"image__subtitle\">What determines whether a blood vessel remains elastic for decades or ruptures unexpectedly? It is a question that not only keeps doctors, but especially patients awake. Within the CELLSYSTEMICS project, Koen Reesink of the Cardiovascular Research Institute Maastricht (Maastricht UMC) investigates how the human vascular wall works, reacts and sometimes fails, using a unique human measurement model.<\/span>\n\t\t\t\t\t\t\n\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/nieuws\/leven-met-een-tikkende-tijdbom\/\" target=\"_blank\" class=\"image__button button button--secondary\">Read more<\/a>\n\t\t\t\t\t\t\t<\/div>\n\t\t\n\t\t\t\t\t<div class=\"image__overlay\"><\/div>\n\t\t\n\t\t<img decoding=\"async\" width=\"1728\" height=\"1080\" src=\"https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-1728x1080.jpg\" class=\"attachment-image_block size-image_block\" alt=\"\" style=\"object-position: center center;\" srcset=\"https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-1728x1080.jpg 1728w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-300x188.jpg 300w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-1024x640.jpg 1024w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-768x480.jpg 768w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-1536x960.jpg 1536w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-18x12.jpg 18w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-576x360.jpg 576w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-453x283.jpg 453w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-200x125.jpg 200w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2-1280x800.jpg 1280w, https:\/\/fhi.nl\/app\/uploads\/2025\/07\/Ontwerp-zonder-titel-2.jpg 1920w\" sizes=\"(max-width: 1728px) 100vw, 1728px\" \/>\t<\/div>\n\t<\/div><\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":41,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"branches":[14],"events":[369],"secretariat":[],"categories":[59,32],"themes_tax":[517],"class_list":["post-80016","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - 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