{"id":80392,"date":"2026-03-20T11:09:07","date_gmt":"2026-03-20T10:09:07","guid":{"rendered":"https:\/\/fhi.nl\/?page_id=80392"},"modified":"2026-03-20T11:21:50","modified_gmt":"2026-03-20T10:21:50","slug":"beyond-2d-cell-culture-emulating-skeletal-tissue-microenvironments-through-3d-bioprinting","status":"publish","type":"page","link":"https:\/\/fhi.nl\/en\/beyond-2d-cell-culture-emulating-skeletal-tissue-microenvironments-through-3d-bioprinting\/","title":{"rendered":"Beyond 2D Cell culture: emulating skeletal tissue microenvironments through 3D bioprinting"},"content":{"rendered":"<header id=\"header\" class=\"header header--high header--branch\">\n\n\t\n\t\n\t<div class=\"container\">\n\t\t<div class=\"header__content\">\n\t\t\t<div class=\"header__first\">\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"header__navigation-button\">\n\t\t\t\t\t\t<a class=\"header__navigation-button__arrow\" target=\"_self\" href=\"https:\/\/fhi.nl\/en\/lifescience\/programma\/\">\n\t\t\t\t\t\t\t<svg width=\"56\" height=\"33\" viewbox=\"0 0 56 33\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><rect x=\"56\" y=\"33\" width=\"56\" height=\"33\" rx=\"16.5\" transform=\"rotate(180 56 33)\" fill=\"#ffda56\"\/><path d=\"M22.262 22.456 16.294 16.5l5.968-5.956M39.706 16.5H16.293\" stroke=\"#fff\" stroke-width=\"2\" stroke-linecap=\"round\"\/><\/svg> To program\t\t\t\t\t\t<\/a>\n\t\t\t\t\t<\/div>\n\t\t\t\t\n\t\t\t\t\n\t\t\t\t<h1 class=\"header__title\" >\n\t\t\t\t\tBeyond 2D Cell culture: emulating skeletal tissue microenvironments through 3D bioprinting\t\t\t\t<\/h1>\n\n\t\t\t\t<div class=\"header__dots-line\">\n\t\t\t\t\t<svg width=\"431\" height=\"9\" viewbox=\"0 0 431 9\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M430.799 4.192a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.135 1.135 0 1 1-2.27 0 1.135 1.135 0 0 1 2.27 0Zm-27.27 0a1.136 1.136 0 1 1-2.272-.001 1.136 1.136 0 0 1 2.272 0Zm-27.272 0a1.39 1.39 0 1 1-2.78 0 1.39 1.39 0 0 1 2.78 0Zm-27.78 0a1.645 1.645 0 1 1-3.29 0 1.645 1.645 0 0 1 3.29 0Zm-28.29 0a1.9 1.9 0 1 1-3.799 0 1.9 1.9 0 0 1 3.799 0Zm-28.799 0a2.154 2.154 0 1 1-4.308 0 2.154 2.154 0 0 1 4.308 0Zm-29.308 0a2.41 2.41 0 1 1-4.819 0 2.41 2.41 0 0 1 4.819 0Zm-29.819 0a2.663 2.663 0 1 1-5.326.001 2.663 2.663 0 0 1 5.326-.001Zm-30.327 0a2.919 2.919 0 1 1-5.837 0 2.919 2.919 0 0 1 5.837 0Zm-30.837 0a3.173 3.173 0 1 1-6.345.001 3.173 3.173 0 0 1 6.345 0Zm-31.346 0a3.428 3.428 0 1 1-6.856 0 3.428 3.428 0 0 1 6.856 0Zm-31.856 0a3.683 3.683 0 1 1-7.365 0 3.683 3.683 0 0 1 7.365 0Zm-32.365 0a3.937 3.937 0 1 1-7.875 0 3.937 3.937 0 0 1 7.875 0Zm-32.874 0a4.192 4.192 0 1 1-8.384 0 4.192 4.192 0 0 1 8.384 0Z\" fill=\"#FFF960\"\/><\/svg>\t\t\t\t<\/div>\n\n\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"header__description\">\n\t\t\t\t\t\t\t<p>Dr. ir. Marco Domingos<\/p>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\n\t\t\t<\/div>\n\n\t\t\t\t\t\t\t<div class=\"header__second\">\n\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\t\t\t\t\t\t<div class=\"header__branch-logos\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" src=\"https:\/\/fhi.nl\/app\/uploads\/2024\/02\/Laboratorium-technologie.svg\" class=\"header__branch-logo\" alt=\"\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t\t\n\t\t\t\t<\/div>\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/header>\n\n\t<div class=\"header__meta\">\n\t<div class=\"container\">\n\t\t<div class=\"header__meta__category\">\n\n\t\t\t\t\t\t\t<div class=\"header__meta__detail\">\n\t\t\t\t\t<div>Branch<\/div>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<a href=\"https:\/\/fhi.nl\/en\/kennishub\/?_branches_kennishub=laboratorium-technologie\" class=\"header__meta__detail--branch\">\n\t\t\t\t\t\t\t\tLaboratory Technology\t\t\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\n\t\t\t\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\n\n<div class=\"text bg--offwhite\">\n\t<div class=\"container\">\n\t\t\t\t\t<div class='heading-wrapper'><svg width=\"13\" height=\"13\" viewbox=\"0 0 13 13\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"6.394\" cy=\"6.5\" r=\"6.394\" fill=\"#000\"\/><\/svg><h2>11:00 \u2013 11:30<\/h2><\/div>\t\t\t\t\t\t<div class=\"text__content text__content--1-col\">\n\t\t\t<p>Most cell culture models are limited not by the cells themselves, but by the environments in them<br \/>\nwhich we place them. Traditional two-dimensional (2D) systems provide limited control over<br \/>\nthe structural and biochemical cues that regulate cell function, restricting their ability to capture<br \/>\nnative tissue complexity. In this talk, I will show how 3D bioprinting can be used to engineer<br \/>\nmore physiologically relevant cell culture models by recreating key features of the extracellular<br \/>\nmatrix (ECM). Our approach focuses on the design of biomaterials and bioinks that mimic the<br \/>\ncomposition and function of tissues such as bone, cartilage or meniscus, enabling controlled<br \/>\ncell-material interactions and guiding stem cell behavior. By combining multiple<br \/>\nbiofabrication techniques, we can generate 3D models with defined architecture and spatial<br \/>\norganization, going beyond conventional culture systems. These models offer improved<br \/>\nplatforms for studying tissue function and regeneration. Ultimately, this talk highlights how<br \/>\nbiofabrication can help bridge the gap between simplified in vitro systems and the complexity<br \/>\nof human tissues, enabling more predictive and biologically relevant models for therapy<br \/>\ndevelopment and drug screening.<\/p>\n<p>\u2013 Marco Domingos \u2013<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n<div class=\"image-text bg--light-blue\">\n\t<div class=\"container\">\n\t\t<div class=\"image-text__wrapper\">\n\t\t\t<div class=\"image-text-image\">\n\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"472\" height=\"283\" src=\"https:\/\/fhi.nl\/app\/uploads\/2026\/03\/Ontwerp-zonder-titel-48-472x283.png\" class=\"attachment-image_text_block size-image_text_block\" alt=\"\" srcset=\"https:\/\/fhi.nl\/app\/uploads\/2026\/03\/Ontwerp-zonder-titel-48-472x283.png 472w, https:\/\/fhi.nl\/app\/uploads\/2026\/03\/Ontwerp-zonder-titel-48-300x180.png 300w, https:\/\/fhi.nl\/app\/uploads\/2026\/03\/Ontwerp-zonder-titel-48-18x12.png 18w, https:\/\/fhi.nl\/app\/uploads\/2026\/03\/Ontwerp-zonder-titel-48-200x120.png 200w, https:\/\/fhi.nl\/app\/uploads\/2026\/03\/Ontwerp-zonder-titel-48.png 500w\" sizes=\"(max-width: 472px) 100vw, 472px\" \/>\t\t\t\t  <label><\/label>\n\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<div class=\"image-text-content\">\n\t\t\t\t\t\t\t\t\t<div class='heading-wrapper'><svg width=\"13\" height=\"13\" viewbox=\"0 0 13 13\" fill=\"none\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><circle cx=\"6.394\" cy=\"6.5\" r=\"6.394\" fill=\"#000\"\/><\/svg><h2 class='image-text-content__title'>Biography<\/h2><\/div>\t\t\t\t\n\t\t\t\t\t\t\t\t\t<div class=\"image-text-content__text\"><p>Marco Domingos is an Associate Professor in the Department of Mechanical and Aerospace<br \/>\nEngineering at the University of Manchester (UK) and Technology Platform Lead for<br \/>\nBioprinting at the Henry Royce, the UK&#039;s national institute for advanced materials<br \/>\n(h<a href=\"https:\/\/www.royce.ac.uk\/\">ttps:\/\/www.royce.ac.uk<\/a>). His research sits at the interface of engineering, biology and<br \/>\nmaterials science, focusing on advanced biofabrication technologies for regenerative medicine,<br \/>\ndisease modeling and drug screening. He has authored over 65 peer-reviewed publications<br \/>\nthe field of biomaterials and biofabrication, with more than 5,000 (h-index: 33). He is a Fellow<br \/>\nof the Higher Education Academy (FHEA) and the Institution of Mechanical Engineers<br \/>\n(FIMechE). He also holds visiting professorships at CDRSP (Portugal) and the University of<br \/>\nNaples Federico II (Italy) and serves on the scientific advisory boards of international biotech<br \/>\ncompanies, supporting the translation of biofabrication technologies and biomaterials research<br \/>\ntoward clinical and industrial applications.<\/p>\n<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t<\/div>\n<\/div>","protected":false},"excerpt":{"rendered":"","protected":false},"author":41,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"branches":[14],"events":[369],"secretariat":[],"categories":[],"themes_tax":[517],"class_list":["post-80392","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.8 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Beyond 2D Cell culture: emulating skeletal tissue microenvironments through 3D bioprinting - 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