Andrew Stubbs completed his PhD at United Medical and Dental School and subsequently employed novel methods for target discovery in prostate cancer research at Royal Postgraduate School of Medicine (Imperial College) at London University, UK. His training in bioinformatics at both London University and at the European Bioinformatics Institute has allowed him to employ a combination of experimental and data-mining techniques to address scientific challenges in relation to cancer, cardiovascular and immunological disease pathology and towards targeted treatment. In his ten years of drug discovery experience at GlaxoSmithkline (UK) and Johnson and Johnson, PRD (Belgium), where, as the Bioinformatics team leader, he developed an automated microarray analysis and knowledge management application, and implemented a Bayesian modeling approach to target (and pathway) identification for kinase inhibitors.
Andrew heads the Translational Bioinformatics team which is responsible for developing reusable strategies and software directed at solving clinically relevant problems in cancer, immunology, cardiovascular disease and clinical genetics. His team is responsible for implementing Huvariome (huvariome.erasmusmc.nl), a web server resource of whole-genome next-generation sequencing allelic frequencies to aid in pathological candidate gene selection. To support somatic mutation analysis his team developed iFUSE a web-based fusion gene explorer and for implementing a national CLOUD based next generation sequencing toolbox for Complete Genomics whole genome sequencing and an integrated RNASeq platform, single nucleotide to fusion gene detection underdevelopment on the same Galaxy CLOUD.
In two Cardiovascular CTMM (Center for Translational and Molecular Medicine) research projects, TRIUMPH and Circulating Cells, a multi-“omics” statistical analysis platform has been developed to successfully identify clinically relevant multi-marker biomarker panels to improve the prediction of outcome in cardiovascular disease.
Andrew Stubbs, Erasmus MC