In the laboratory sector, legislation and regulations are important because you work with critical processes, (bio)chemical substances, equipment, and data. Rules and standards ensure safety, reliable results, and good quality. Examples include quality standards (such as ISO 15189 and ISO/IEC 17025), requirements regarding working with substances and mixtures (REACH/CLP), transport and storage (e.g., ADR), and regulations concerning occupational health and safety, the environment, and waste streams. Additionally, more and more sustainability and supply chain requirements are being added, for example regarding procurement, product information, reporting, and circularity. For labs and suppliers, this means looking not only at performance and compliance but also at origin, energy consumption, lifespan, repair, and waste processing. The challenge is to comply with the regulations while simultaneously taking practical steps that fit the daily work in and around the lab.