LC-MS demands consistent, high-quality sample preparation
LC-MS delivers high sensitivity and selectivity across small molecule and biologics applications, but analytical performance is directly dependent on upstream sample preparation. Automating critical steps such as aliquoting, protein precipitation, extraction, and clean-up reduces variability and supports reproducible, reliable results at scale.
For a broader overview of automated LC-MS workflows in analytical chemistry, visit our
LC-MS applications page:
https://www.hamiltoncompany.com/applications/analytical-chemistry/liquid-chromatography-mass-spectrometry-lc-ms
Automation enables scalable and traceable LC-MS workflows
As sample volumes increase and workflows become more complex, manual preparation limits throughput and standardization. Automated LC-MS sample preparation improves efficiency, minimizes hands-on time, and supports traceability across regulated and research environments—from primary sample handling through final analysis.
For deeper insights into regulated LC-MS applications, explore our Knowledge Center resources:
- LC-MS Analysis in Therapeutic Drug Monitoring
https://www.hamiltoncompany.com/knowledge-base/ebook/liquid-chromatography-mass-spectrometry-lc-ms-analysis-in-therapeutic-drug-monitoring - LC-MS Analysis for Drugs of Abuse Testing
https://www.hamiltoncompany.com/knowledge-base/ebook/liquid-chromatography-mass-spectrometry-lc-ms-analysis-for-drugs-of-abuse-testing - LC-MS Analysis for Biopharmaceutical Research
https://www.hamiltoncompany.com/knowledge-base/ebook/lc-ms-analysis-for-biopharmaceutical-research
Hamilton provides modular automation tailored to LC-MS workflows
Hamilton combines precision liquid handling with integrated technologies for LC-MS sample preparation, from primary tube handling to final clean-up. Systems such as MassSTAR® and Dual MassSTAR® are designed to support robust protein precipitation workflows, while modular platforms and assay-ready workstations allow laboratories to automate exactly the steps they need today—and remain flexible as methods and throughput requirements evolve.
Learn more about Dual MassSTAR® for automated LC-MS sample preparation:
https://www.hamiltoncompany.com/dual-massstar
Visit the Hamilton booth no. 13 at LabAutomation 2026 and discuss your LC-MS workflow with our specialists.